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Some Bacteria Sacrifice Themselves to Protect their Brethren from Antibiotics

Some Bacteria Sacrifice Themselves to Protect their Brethren from Antibiotics

Scientists at The University of Texas at Austin have discovered how some cells within a bacterial swarm will sacrifice themselves so that other cells in the swarm have a better chance of surviving onslaught by antibiotics, in a discovery important for efforts to address antibiotic resistance.

As bacterial cells within a cluster or swarm die, they release chemical death cries, which scientists call necrosignaling. These signals act like a kind of early warning system, allowing the surviving bacterial cells to prepare a type of resistance to antibiotics. The process of necrosignaling is outlined in a new paper out today in Nature Communications.

Bacterial swarms occur when certain types of bacteria, like E. coli, band together by the billions and use their whip-like flagella to move as one over a solid surface. Scientists have previously observed that these swarms are more resistant to antibiotics and knew that dead bacteria provide nutrients to surviving bacteria in the swarm. However, this is the first time an active signal has been uncovered.

Rasika Harshey, the Lorene Morrow Kelley Professor of Microbiology, and her team had observed almost a decade ago that when bacterial swarms moved into an area that was treated with antibiotics, about 25% of the cells in the swarm died. They wondered if this massive cell death was altruistic in actually helping the community as a whole survive. The results in the paper out today show that this is true. As they died, the cells released a protein that would bind to the surface of the surviving bacterial cells. This acted like a signal, letting survivors in the bacterial swarm know to start pumping the antibiotic out of the cells using specialized molecular machines called efflux pumps.

"While this resistance is physiological, it buys the bacteria time to acquire mutations that would eventually lead to genetic resistance," Harshey said.

Antibiotic-resistant bacteria represent a critical problem in medicine because once a bacterium becomes resistant to several types of antibiotic medications, it becomes incredibly difficult to treat infections in humans and animals.

By understanding one of the mechanisms by which these hard-to-kill swarms survive contact with antibiotics, scientists may be able to target that process with therapeutic drugs.

"Interfering with necrosignaling should enhance the efficacy of antibiotics and reduce the occurrence of drug-resistant strains," Harshey said.

Harshey and her team discovered through their research that within the bacterial swarm, a subpopulation of cells appears to be more susceptible to antibiotics, like a kind of bacterial cannon fodder. By developing these different types of cells, the swarm has a better chance of survival than single bacterial cells.

"Many clinically important bacteria go through phases of their infection cycle outside the host in harsh environments where swarming would increase their chances of acquiring antibiotic resistance through necrosignaling," Harshey said. "With better understanding of this process we may be able to halt it."

The research was carried out at UT Austin by Souvik Bhattacharyya, and David M. Walker also contributed. The research was funded by the National Institutes of Health and the Robert Welch Foundation.

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Wednesday, 28 October 2020

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