Chemist’s Innovation Spurs Drugs that Hang on Through Thick and Thin

October 27, 2023 • by Emily Engelbart

The newly launched Hyku Biosciences provides a platform for covalent drug development which may be a better approach for treating diseases like cancer.

Using SuTex, short for sulfur-triazole exchange chemistry, Ken Hsu has created an approach to target sites on proteins that have extra electrons to share. This covalent bond is very stable compared with bonds formed by traditional drugs. Credit: Zhihong Li

One of Hsu's SuTEx molecules targets sites on proteins that have extra electrons to share. Drugs that bond covalently have a more stable attachment compared to traditional drugs. Credit: Zhihong Li


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