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Wei, Xuexin

Xuexin Wei

Assistant Professor
Department of Neuroscience, Department of Psychology


Office Location


Xue-Xin Wei grew up in Qingdao (or Tsingtao, known for Tsingtao Beer), China. After obtaining a Bachelor degree in mathematics and applied mathematics at Peking University, he became fascinated by the inner workings of the brain. In 2010 he moved to UPenn to pursue a Ph.D in psychology. He was the recipient of Louis B. Flexner Award, which gives to the Outstanding Thesis Work on any topics related to Neurosciences at UPenn. Since 2016, he has been working as a postdoctoral research scientist at Center for Theoretical Neuroscience & Department of Statistics at Columbia University.  In January 2020, Xue-Xin will start as an Assistant professor in Department of Neuroscience. 

Xue-Xin can be reached at weixxpku@gmail.com




The lab aims to understand how brain/neurons generate adaptive and intelligent behavior. To tackle this fundamental question, we take a combination of bottom-up (analyzing experimental data and construct constrained mechanistic models ) and top-down (normative models) approach.  Our research covers a variety of topics, including 1) using efficient computation as a guiding principle to understand cognition; 2) sensory adaptation; 3) normative models of visual physiology and perception; 4) understanding neural coding through geometry; 5) generalization in the brain and artificial intelligence systems; 6) building probabilistic models of neural population responses. Much of the research is in the domains of vision and navigation. 

The lab works at the intersection of Computational Neuroscience, Statistics, and AI/deep learning. We leverage the computational power of deep learning to help understand computations in the brain.  We are also interested in using the prior knowledge and constraints obtained from the brain to develop more powerful AI systems. We work closely with experimentalists to develop sophisticated statistical techniques to understand how the neural responses are determined by the inputs and internal states on a trial-by-trial basis. These statistical models could provide specific constraints on the operations at the neural circuit level.  As a further step, we can construct quantitative models constrained by these observations to reveal computational mechanisms underlying neural computation.

We are looking for motivated graduate students, undergraduate students and postdocs to work on these problems together. Currently, there are multiple openings in the lab. Please get in touch if you are interested. 

Xue-Xin can be reached at weixxpku@gmail.com



1. A zero-inflated gamma model for post-deconvolved calcium imaging traces. Xue-Xin Wei*, Ding Zhou*, Andres Grosmark, Zaki Ajabi, Fraser Sparks, Pengcheng Zhou, Mark Brandon, Attila Losonczy, and Liam Paninski.  bioRxiv preprint (2019): 637652. (In revision)

2. Dynamic self-organized error-correction of grid cells by border cells. Eli Pollock, Niral Desai, Xue-Xin Wei*, and Vijay Balasubramanian*. arXiv preprint, arXiv:1808.01503, 2018 (In revision).

3. Emergence of grid-like representation by training recurrent neural networks to perform spatial localization. Christopher J Cueva*, Xue-Xin Wei*, International Conference on Learning Representations (ICLR), 2018 (top 1% of all submissions).

4. The lawful relation between perceptual bias and discriminability.   Xue-Xin Wei, Alan A. Stocker,  Proc. National Academy of Sciences, Sept., 2017.

5. Mutual Information, Fisher Information, and Efficient Coding.   Xue-Xin Wei, Alan A Stocker.   Neural Computation, 2016.

6. Efficient neural codes under metabolic constraints.   Zhuo Wang*, Xue-Xin Wei*, Alan A. Stocker, and Daniel D. Lee. Neural Information Processing Systems (NIPS), Dec, 2016.          

7. A Bayesian observer model constrained by Efficient coding can explain “anti-Bayesian” percepts.   Xue-Xin Wei, Alan A Stocker.   Nature Neuroscience 18, no. 10 (2015): 1509-1517.

8. A principle of economy predicts the functional architecture of the grid cells.  Xue-Xin Wei, Jason Prentice, Vijay Balasubramanian.   eLife (2015) : e08362. 

9. Efficient coding connects prior and likelihood function in perceptual Bayesian inference.  Xue-Xin Wei and Alan A Stocker.  Neural Information Processing Systems (NIPS), Lake Tahoe CA, December 2012, MIT Press.