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Bacteria Help Scientists Discover Human Cancer-Causing Proteins

Bacteria Help Scientists Discover Human Cancer-Causing Proteins

Researchers genetically modified E coli bacteria to fluoresce red when DNA was damaged. Then, they overexpressed each of the bacteria’s 4,000 genes individually and determined which proteins made bacteria glow red. With these bacterial proteins as a guide, they identified more than 100 analogous human proteins that are now implicated in DNA damage and initiation of cancer. Image credit: Jun Xia.

A team led by researchers at The University of Texas at Austin and Baylor College of Medicine has applied an unconventional approach involving bacteria to discover human proteins that can lead to DNA damage and promote cancer. This could lead to new tests to identify people who are likely to develop cancer. Reported in the journal Cell, the study also proposes biological mechanisms by which these proteins can damage DNA, opening possibilities for future cancer treatments.

Two UT Scientists Part of Project to Detect ‘Life As We Don’t Know It’

Two UT Scientists Part of Project to Detect ‘Life As We Don’t Know It’

Eric Anslyn and Andrew Ellington.

A nearly $7 million grant from NASA is supporting research to develop approaches to detecting extraterrestrial life, and two University of Texas at Austin faculty are part of the interdisciplinary scientific team.

18 Notable and Newsworthy Texas Science Stories from 2018

18 Notable and Newsworthy Texas Science Stories from 2018

It's been a big year for Texas Science, with news about research, new discoveries, technological advancements and awards making headlines around the world. Here are a few UT Austin science stories that made the news in 2018.

UT Scientists, Mathematicians and High Schoolers Partner for Success

UT Scientists, Mathematicians and High Schoolers Partner for Success

Gold medalists in an astrophysics Olympic-style event, award-winners at a statewide science fair and budding genetic engineers who shared their research 2,000 miles away are among the high schoolers who found success after working closely with members of the Texas Science community in 2018.

New Flu Drug Informed by UT Austin Professor's 40-year-old Basic Research

New Flu Drug Informed by UT Austin Professor's 40-year-old Basic Research

Last year, Texas saw a particularly deadly flu season. Now, there is a new Federal Drug Administration-approved treatment, Xofluza, designed to catch the flu in its early stages and stop it from spreading. The drug is thanks in large part to professor emeritus Robert Krug's basic research, undertaken almost 40 years ago.

New Protein Sequencing Method Could Transform Biological Research

New Protein Sequencing Method Could Transform Biological Research

An ultra-sensitive new method for identifying the series of amino acids in individual proteins (a.k.a. protein sequencing) can accelerate research on biomarkers for cancer and other diseases. Credit: David Steadman/University of Texas at Austin.

A team of researchers at The University of Texas at Austin has demonstrated a new way to sequence proteins that is much more sensitive than existing technology, identifying individual protein molecules rather than requiring millions of molecules at a time. The advance could have a major impact in biomedical research, making it easier to reveal new biomarkers for the diagnosis of cancer and other diseases, as well as enhance our understanding of how healthy cells function.

Visualizing Science 2018: Beauty and Inspiration in College Research

Visualizing Science 2018: Beauty and Inspiration in College Research

Over the last six years, faculty, staff and students from across the College of Natural Sciences have submitted hundreds of images from their scholarly research for our annual Visualizing Science competition, and these images have been viewed by tens of thousands of people. The submitted images, often beautiful and stunning, are the ones that spoke to their creators, inspiring and informing them as they followed their scientific passions.

Two Studies Shed Light on How Complex CRISPR Systems Work

Two Studies Shed Light on How Complex CRISPR Systems Work

In a pair of papers out this week, scientists at the University of Texas at Austin made new discoveries about a remarkable naturally occurring system known as CRISPR.

UT Austin Alum James Allison Awarded Nobel Prize

UT Austin Alum James Allison Awarded Nobel Prize

James P. Allison, a world-renowned pioneer of cancer immunotherapy, has been awarded the 2018 Nobel Prize in physiology or medicine jointly with Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation."

Of Fruit Flies, Nobel Prizes and Genetic Discoveries that Change the World (Audio)

Of Fruit Flies, Nobel Prizes and Genetic Discoveries that Change the World (Audio)

Last year, University of Texas at Austin alumnus Michael Young won the Nobel Prize in Physiology or Medicine for discovering the molecular mechanism behind circadian rhythms. Circadian clocks are critical for the health of all living things, acting as the internal timekeepers in plants and animals that help to synchronize functions like eating and sleeping with our planet's daily rhythm of light and dark.