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Early Spread of COVID-19 Appears Far Greater Than Initially Reported

Early Spread of COVID-19 Appears Far Greater Than Initially Reported

Patients with undiagnosed flu symptoms who actually had COVID-19 last winter were among thousands of undetected early cases of the disease at the beginning of this year. In a new paper in The Lancet's open-access journal EClinicalMedicine, epidemiological researchers from The University of Texas at Austin estimated COVID-19 to be far more widespread in Wuhan, China, and Seattle, Washington, weeks ahead of lockdown measures in each city.

Locking Down Shape-Shifting Spike Protein Aids Development of COVID-19 Vaccine

Locking Down Shape-Shifting Spike Protein Aids Development of COVID-19 Vaccine

An engineered protein developed by UT Austin researchers and their colleagues is a key element of COVID-19 vaccines currently in human trials by Moderna, Novavax, Pfizer-BioNTech and Johnson & Johnson.

The experimental vaccine against SARS-CoV-2 that was the first to enter human trials in the United States has been shown to elicit neutralizing antibodies and a helpful T-cell response with the aid of a carefully engineered spike protein that mimics the infection-spreading part of the virus.

New Tool to Guide Decisions on Social Distancing Uses Hospital Data and Emphasizes Protecting the Vulnerable

New Tool to Guide Decisions on Social Distancing Uses Hospital Data and Emphasizes Protecting the Vulnerable

With communities throughout the United States combating surges in COVID-19 cases and hospitalizations, researchers at The University of Texas at Austin and Northwestern University have created a framework that helps policymakers determine which data to track and when to take action to protect their communities. The model specifies a series of trigger points to help local entities know when to tighten social distancing measures to prevent hospitals from being overrun by virus patients. The method also aims to minimize the economic impact to communities by suggesting the earliest times for safely relaxing restrictions.

COVID-19 Vaccine Innovation Could Dramatically Speed Up Worldwide Production

COVID-19 Vaccine Innovation Could Dramatically Speed Up Worldwide Production

Jason S. McLellan, associate professor of molecular biosciences, left, and graduate student Daniel Wrapp, right, work in the McLellan Lab at The University of Texas at Austin Monday Feb. 17, 2020.

Responding to a need to quickly develop billions of doses of lifesaving COVID-19 vaccines, a scientific team at The University of Texas at Austin has successfully redesigned a key protein from the coronavirus, and the modification could enable much faster and more stable production of vaccines worldwide.

Discovery about Hep C Drug Offers Insights for Coronavirus Treatments

Discovery about Hep C Drug Offers Insights for Coronavirus Treatments

Researchers at the University of Texas at Austin have discovered how a certain drug is able to stop viral spread for patients with Hepatitis C, and the finding may have important implications for drug developers seeking to stop other RNA viruses, including the virus that causes COVID-19.

COVID-19 Vaccines with UT Ties Arrived Quickly After Years in the Making

COVID-19 Vaccines with UT Ties Arrived Quickly After Years in the Making

From left: Jason S. McLellan, associate professor of molecular biosciences, Daniel Wrapp, graduate student, and Nianshuang Wang, research associate, pose for a photo in the McLellan Lab at The University of Texas at Austin Monday Feb. 17, 2020. Credit: Vivian Abagiu.

When the first COVID-19 vaccine trial in the U.S. began on March 16, history was being made. Never before had a potential vaccine been developed and produced for human trials so quickly—just 66 days since scientists published the genome sequence of the virus that causes the disease. This blindingly fast effort was only possible because a group of scientists and their partners in industry had already invested years in laying the groundwork.

New Sensor May Soon Test for Coronavirus and Flu Simultaneously

New Sensor May Soon Test for Coronavirus and Flu Simultaneously

The novel coronavirus has been compared to the flu almost from the moment it emerged in late 2019. They share a variety of symptoms, and in many cases, an influenza test is part of the process for diagnosing COVID-19.

Antibodies from a SARS Patient Could Help Fight Coronaviruses Now and in the Future

Antibodies from a SARS Patient Could Help Fight Coronaviruses Now and in the Future

Scientists from UT Austin and elsewhere found many human antibodies that bind to the spike protein of SARS-like viruses. On the left, two copies of an antibody dubbed ADI-55689 (orange) bind two different sites on the spike protein (white). On the right, a different antibody dubbed ADI-56046 (purple) binds another site on the spike protein. These antibody binding sites are close to sites where the spike protein binds to receptors on the surface of human cells (red) and to another monoclonal antibody dubbed CR3022 (light blue).

As terrifying as the current pandemic is, scientists believe some of the hundreds of other known coronaviruses in bats might also have the potential to make the cross-species leap into humans, as this one probably did. Scientists are already thinking about ways to prevent another coronavirus from spiraling out of control. Basic research published in the journal Science provides evidence that an antibody therapy that's effective against all SARS-like coronaviruses is possible.

COVID-19 Convalescent Plasma Therapy is Safe, With 76% of Patients Improving

COVID-19 Convalescent Plasma Therapy is Safe, With 76% of Patients Improving

The country’s first peer-reviewed study of convalescent plasma transfusion therapy, which uses blood plasma donated by recovered patients to treat currently ill patients, shows 19 out of 25 patients with COVID-19 improving with the treatment. Photo: iStock.

The country's first peer-reviewed study of a COVID-19 treatment that transfuses blood plasma from recovered patients into critically ill patients shows 19 out of 25 patients improving, including 11 discharged from the hospital.

COVID-19 Drug Development Could Benefit from Approach Used Against Flu

COVID-19 Drug Development Could Benefit from Approach Used Against Flu

A new study from researchers at The University of Texas at Austin has found that some antivirals are useful for more than helping sick people get better — they also can prevent thousands of deaths and hundreds of thousands of virus cases if used in the early stages of infection.