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Bacterial Warfare Provides New Antibiotic Target

Bacterial Warfare Provides New Antibiotic Target

Pseudomonas bacteria use a kind of harpoon to attack nearby bacteria, injecting them with a toxin that targets a critical molecular machine called the transamidosome complex. Credit: Despoina Mavridou/University of Texas at Austin.

Antibiotic resistance, where disease-causing bacteria evolve resistance to drugs that usually kill them, is a rising problem globally, meaning new antibiotics need to be found. However, it is difficult for researchers to know which parts of bacterial cells to target with new drugs.

Simulation Reveals How a SARS-CoV-2 ‘Gate’ Opens to Allow COVID Infection

Simulation Reveals How a SARS-CoV-2 ‘Gate’ Opens to Allow COVID Infection

Despite more than a year and a half of research, there are still many unknowns about how the virus that causes COVID-19 infects human cells. A deeper understanding could lead to new treatment approaches.

New Tumor Cell Tracking System Aims to Understand Cancer Treatment Resistance

New Tumor Cell Tracking System Aims to Understand Cancer Treatment Resistance

HeLa cells, a cancerous cell line used by researchers around the world to study a large variety of important research questions. Photo credit: Tom Deerinck, National Center for Microscopy and Imaging Research. Photo courtesy of NIH.

Despite tremendous advances in medicine, tumors are challenging to cure because they are made up of heterogeneous cells. In other words, like human families, the individual cells of a tumor share some common traits and characteristics, but as the tumor expands, the cells also develop their own identities. And, as a result, some cells are more resistant to therapy than others and quicker to adapt and change.

MasSpec Pen Shows Promise in Pancreatic Cancer Surgery

MasSpec Pen Shows Promise in Pancreatic Cancer Surgery

Jialing Zhang demonstrates using the MasSpec Pen on a human tissue sample. Photo credit: Vivian Abagiu/Univ. of Texas at Austin.

A diagnostic tool called the MasSpec Pen has been tested for the first time in pancreatic cancer patients during surgery. The device is shown to accurately identify tissues and surgical margins directly in patients and differentiate healthy and cancerous tissue from banked pancreas samples.

System Linked to Operational Hospitals, Shorter Lockdowns, Lives Saved

System Linked to Operational Hospitals, Shorter Lockdowns, Lives Saved

COVID-19: Risk-Based Guidelines with 7 Day Moving Averages for New Admissions were made available for the Austin metropolitan area as part of a staged alert system. Shown is the City of Austin dashboard for June 16. Credit: City of Austin

A staged alert system, designed by scientists and public health officials to guide local policies, helped one city prevent hospital surges and long lockdowns, according to new research published in the journal Nature Communications.

First Glimpse of Brains Retrieving Mistaken Memories Observed

First Glimpse of Brains Retrieving Mistaken Memories Observed

Scientists have observed for the first time what it looks like in the key memory region of the brain when a mistake is made during a memory trial. The findings have implications for Alzheimer's disease research and advancements in memory storage and enhancement, with a discovery that also provides a view into differences between the physiological events in the brain during a correct memory versus a faulty one.

Forecasting Resources Needed to Protect People Experiencing Homelessness During COVID-19

Forecasting Resources Needed to Protect People Experiencing Homelessness During COVID-19

A new study provides public health planning authorities with a method of calculating the number of COVID-19 isolation beds they would need for people experiencing homelessness based on level of infection in the city. The research holds promise for controlling spread of the virus – or future infectious diseases – in a population that is highly vulnerable and less likely than many others to access health care services.

Changing the World, One Graduate at a Time

Changing the World, One Graduate at a Time

This month, hundreds of graduating College of Natural Sciences students will walk across a small outdoor stage, masked and socially distanced, and smile at the camera for friends and family mostly watching online.

'Last Resort' Antibiotic Pops Bacteria Like Balloons

'Last Resort' Antibiotic Pops Bacteria Like Balloons

A 70-year mystery has finally been solved and the solution could help in the fight against antibiotic resistant bacteria. A new study led by researchers at Imperial College London, and including UT Austin's Despoina Mavridou, reveals that colistin, a last resort antibiotic "punches holes in bacteria, causing them to pop like balloons." Published i...
Our Immune Systems Blanket the SARS-CoV-2 Spike Protein with Antibodies

Our Immune Systems Blanket the SARS-CoV-2 Spike Protein with Antibodies

An analysis of blood plasma samples from people who recovered from SARS-CoV-2 infections shows that most of the antibodies circulating in the blood -- on average, about 84% -- target areas of the viral spike protein outside the receptor binding domain (RBD, green), including the N-terminal Domain (NTD, blue) and the S2 subunit (red, yellow). Illustration credit: University of Texas at Austin.

The most complete picture yet is coming into focus of how antibodies produced in people who effectively fight off SARS-CoV-2 work to neutralize the part of the virus responsible for causing infection. In the journal Science, researchers at The University of Texas at Austin describe the finding, which represents good news for designing the next generation of vaccines to protect against variants of the virus or future emerging coronaviruses.