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Scientists Discover Powerful Potential Pain Reliever

Scientists Discover Powerful Potential Pain Reliever

Stephen Martin (left) and James Sahn have discovered a new pain reliever that acts on a previously unknown pain pathway. Photo Credit: Courtesy of Stephen Martin.

A team of scientists led by chemists Stephen Martin and James Sahn at The University of Texas at Austin have discovered what they say is a powerful pain reliever that acts on a previously unknown pain pathway. The synthetic compound, known as UKH-1114, is as effective at relieving neuropathic pain in injured mice as a drug widely used for pain relief called gabapentin, but it works at a much lower dose, with longer duration of action.

New Technique Enables Safer Gene-Editing Therapy Using CRISPR

New Technique Enables Safer Gene-Editing Therapy Using CRISPR

A CRISPR protein targets specific sections of DNA and cuts them. Scientists have turned this natural defense mechanism in bacteria into a tool for gene editing. Illustration: Jenna Luecke and David Steadman/Univ. of Texas at Austin.

Scientists from The University of Texas at Austin took an important step toward safer gene-editing cures for life-threatening disorders, from cancer to HIV to Huntington's disease, by developing a technique that can spot editing mistakes a popular tool known as CRISPR makes to an individual's genome. The research appears today in the journal Cell.

Chemist Searches for Less Toxic Compound to Preserve Organs

Chemist Searches for Less Toxic Compound to Preserve Organs

A computer simulation shows how DMSO molecules (red, white and yellow) form hydrogen bonds with water molecules (red and white). Credit: Carlos Baiz.

About a third of all deaths in the U.S. could be prevented or substantially delayed by organ transplantation, according to a 2015 report from the U.S. military. The main bottleneck is that there is no practical way to preserve organs for more than a few hours. If you try to freeze a whole organ, water within and between cells forms ice crystals that cause the cells to rupture.

Birth Risks Rise Late in Doctors' Shifts, Researchers Find

Birth Risks Rise Late in Doctors' Shifts, Researchers Find

The number of hours an obstetrician has been on the clock before an unscheduled delivery significantly influences risks to the mother and unborn baby, researchers report.

New Material Could Save Time and Money in Medical Imaging and Environmental Remediation

New Material Could Save Time and Money in Medical Imaging and Environmental Remediation

Chemists at The University of Texas at Austin have developed a material that holds the key to cheap, fast and portable new sensors for a wide range of chemicals that right now cost government and industries large sums to detect. The innovation could lead to major public health gains, as it holds the potential to drastically reduce the costs associated with cleaning-up accidental chemical spills, remediating old industrial sites, detecting radioactive contamination in drinking water, and operating medical and research imaging devices.

Unlocking the Mind's Mysteries

Unlocking the Mind's Mysteries

It's been called the most complicated object in the known universe. But, as UT scientists are learning, the human brain offers five important clues for understanding its wonders.

International Women's Day Kick-Off for Crowdfunding Campaign

International Women's Day Kick-Off for Crowdfunding Campaign

Women in Natural Sciences, a small learning community within the College, has been raising retention rates in science and the academic success rates of its students for years. Now it's looking to the community to help raise support and capacity in the program.

Chemist Sessler Offers Inspiring Story of Persistence

Chemist Sessler Offers Inspiring Story of Persistence

A profile of UT Austin chemist and professor Jonathan Sessler is inspiring scientists to share their stories about what drives them in their work.

Hybrid Antibody Takes Down HIV

Hybrid Antibody Takes Down HIV

George Georgiou, a professor of engineering and molecular biosciences at the University of Texas at Austin, and his colleagues have developed a hybrid antibody that neutralized 99 percent of HIV-1 strains tested. The antibody is based on so-called "broadly-neutralizing antibodies," a group of antibodies from HIV-infected patients that are able to take down an array of rapidly mutating HIV-1 viruses.

UT Austin Leads $29 Million Alcoholism Treatment Consortium

UT Austin Leads $29 Million Alcoholism Treatment Consortium

The National Institutes of Health has awarded an international consortium seeking better pharmaceutical treatments for alcoholism a five-year grant totaling $29 million. The administrative headquarters and several of the projects will be at The University of Texas at Austin, which will receive $8.5 million of the total.