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Monfils, Marie

Marie H Monfils

Department of Psychology, Department of Neuroscience


Office Location
SEA 6.104

Postal Address
AUSTIN, TX 78712

Marie Monfils received her Ph.D. in behavioral neuroscience from the Canadian Centre for Behavioural Neuroscience, under the supervision of Bryan Kolb and Jeffrey Kleim, and her Master’s degree from the University of Calgary with Cam Teskey.  She conducted a postdoctoral fellowship at New York University in Joseph LeDoux’s lab.   She is currently pursuing 3 research streams:  (1) examining the role of brain-derived neurotrophic factor (BDNF) in synaptic and structural plasticity associated with fear memory consolidation, (2) investigating different post-consolidation manipulations that can persistently attenuate fear memories, and (3) uncovering the adaptive purpose of fear memory reconsolidation.

Our lab is currently pursuing 3 research streams:

  1. investigate post-consolidation manipulations that can persistently attenuate fear memories,

  2. isolate the mechanisms that underlie social transmission of fear,

  3. examine the interactions between early experience, and fear learning in adulthood.

We study research questions centered around these topics using a combination of behavioral analyses, in vivo recordings of local field potentials, pharmacological manipulations, and immunohistochemical techniques.

Dominance status predicts social fear transmission in laboratory rats. Jones CE, Monfils MH. Anim Cogn. 2016 Jul 13. [Epub ahead of print] PMID: 27411940

Extinction and Retrieval + Extinction of Conditioned Fear Differentially Activate Medial Prefrontal Cortex and Amygdala in Rats. Lee HJ, Haberman RP, Roquet RF, Monfils MH. Front Behav Neurosci. 2016 Jan 22;9:369. doi: 10.3389/fnbeh.2015.00369. eCollection 2015. PMID: 26834596

Assessing Fear Following Retrieval + Extinction Through Suppression of Baseline Reward Seeking vs. Freezing. Shumake J, Monfils MH. Front Behav Neurosci. 2015 Dec 23;9:355. doi: 10.3389/fnbeh.2015.00355. eCollection 2015. PMID: 26778985

Fight, Flight, or Freeze? The Answer May Depend on Your Sex. Jones CE, Monfils MH. Trends Neurosci. 2016 Feb;39(2):51-3. doi: 10.1016/j.tins.2015.12.010. Epub 2016 Jan 6. PMID: 26776563

Extinction, applied after retrieval of auditory fear memory, selectively increases zinc-finger protein 268 and phosphorylated ribosomal protein S6 expression in prefrontal cortex and lateral amygdala. Tedesco V, Roquet RF, DeMis J, Chiamulera C, Monfils MH. Neurobiol Learn Mem. 2014 Nov;115:78-85. doi: 10.1016/j.nlm.2014.08.015. Epub 2014 Sep 6. PMID: 25196703

Therapeutic benefits of methylene blue on cognitive impairment during chronic cerebral hypoperfusion. Auchter A, Williams J, Barksdale B, Monfils MH, Gonzalez-Lima F. J Alzheimers Dis. 2014;42 Suppl 4:S525-35. doi: 10.3233/JAD-141527. PMID: 25079810

Predictability and heritability of individual differences in fear learning. Shumake J, Furgeson-Moreira S, Monfils MH. Anim Cogn. 2014 Sep;17(5):1207-21. doi: 10.1007/s10071-014-0752-1. Epub 2014 May 5.

Updating appetitive memory during reconsolidation window: critical role of cue-directed behavior and amygdala central nucleus. Olshavsky ME, Song BJ, Powell DJ, Jones CE, Monfils MH, Lee HJ. Front Behav Neurosci. 2013 Dec 9;7:186. doi: 10.3389/fnbeh.2013.00186.