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FINKELSTEIN, ILYA J
Yes

Ilya J Finkelstein

Associate Professor
Molecular Biosciences

Lorene Morrow Kelley Endowed Faculty Fellowship Fund

Discovery & Biophysical Studies of Molecular Machines

ifinkelstein@cm.utexas.edu

Phone: 512-471-1394

Office Location
MBB 3.422

Latest publications

Dr. Ilya Finkelstein is an Associate Professor of Molecular Biosciences at the University of Texas at Austin. Prior to his position at UT-Austin, Dr. Finkelstein received a B.S. from the University of California, Berkeley, a Ph.D. in Chemistry from Stanford University, and completed postdoctoral training at Columbia University Medical Center. Dr. Finkelstein’s lab is investigating the molecular mechanisms of genome maintenance, CRISPR biology, and epigenetic inheritance. Since 2019, the Finkelstein lab is also working on pandemic countermeasures with the goal of understanding viral variants and designing better vaccines.

Lab website: https://finkelsteinlab.org/

Prospective students and postdocs are encouraged to reach out via e-mail.

 

Latest publications

Google Scholar

Finkelstein lab website (with PDFs)

Preprints

 
Kamyab Javanmardi†, Thomas H. Segall-Shapiro, Chia-Wei Chou, Daniel R. Boutz, Randall J. Olsen, Xuping Xie, Hongjie Xia, Pei-Yong Shi, Charlie D. Johnson, Ankur Annapareddy, Scott Weaver, James M. Musser, Andrew D. Ellington, Ilya J. Finkelstein†, Jimmy D. Gollihar†(† co-corresponding)
BioRxiv.
[PDF]    [Supplement]    DOI: 10.1101/2022.04.18.488614    
 
Yu-An Kuo, Cheulhee Jung, Yu-An Chen, Hung-Che Kuo, Oliver S. Zhao, Truong D. Nguyen, James R. Rybarski, Soonwoo Hong, Yuan-I Chen, Dennis C. Wylie, John A. Hawkins, Jada N. Walker, Samuel W. Shields, Jennifer S. Brodbelt, Jeffrey T. Petty, Ilya J. Finkelstein, and Hsin-Chih Yeh)
BioRxiv.
[PDF]    [Supplement]    DOI: 10.1101/2021.12.04.471212    
 
Kaylee E. Dillard†, Cynthia Terrace, Kamyab Javanmardi, Wantae Kim, Kevin J. Forsberg, and Ilya J. Finkelstein† († co-corresponding)
BioRxiv.
[PDF]    [Supplement]    DOI: 10.1101/2021.09.15.460536   
 
Jule Goike*, Ching-Lin Hsieh*, Andrew Horton*, Elizabeth C. Gardner*, Foteini Bartzoka, Nianshuang Wang, Kamyab Javanmardi, Andrew Herbert, Shawn Abbassi, Rebecca Renberg, Michael J. Johanson, Jose A. Cardona, Thomas Segall-Shapiro, Ling Zhou, Ruth H. Nissly, Abhinay Gontu, Michelle Byrom, Andre C. Maranhao, Anna M. Battenhouse, Varun Gejji, Laura Soto-Sierra, Emma R. Foster, Susan L. Woodard, Zivko L. Nikolov, Jason Lavinder, Will N. Voss, Ankur Annapareddy, Gregory C. Ippolito, Andrew D. Ellington, Edward M. Marcotte, Ilya J. Finkelstein, Randall A. Hughes, James M. Musser, Suresh V. Kuchipudi, Vivek Kapur, George Georgiou, John M. Dye, Daniel R. Boutz†, Jason S. McLellan†, & Jimmy D. Gollihar† (* co-first authors) († co-corresponding)
BioRxiv.
[PDF]    [Supplement]    DOI: 10.1101/2021.04.07.438849   
 

2022

 
Alexander G Kozlov, Xian Cheng, Hongshan Zhang, Min Kyung Shinn, Elizabeth Weiland, Binh Nguyen, Irina A Shkel, Emily Zytkiewicz, Ilya J Finkelstein, M Thomas Record Jr., Timothy M. Lohman
J Mol Bio. 434 (9): 167562
[PDF]    [Supplement]    DOI: 10.1016/j.jmb.2022.167562    PMID: 35351518    
 
Jeffery M. Schaub†, Michael M. Soniat & Ilya J. Finkelstein†
NAR. 50 (7): 3911-3921
[PDF]    [Supplement]    DOI: 10.1093/nar/gkac119    PMID: 35357490   
 
Behrouz Eslami-Mossallam*, Misha Klein*, Constantijn V. D. Smagt*, Koen V. D. Sanden*, Stephen K. Jones Jr., John A. Hawkins, Ilya J. Finkelstein, and Martin Depken(* co-first authors) († co-corresponding)
Nat Commun.
[PDF]    [Supplement]    DOI: 10.1038/s41467-022-28994-2    PMID: 35292641    
 
Amanda Jack*, Yoonji Kim*, Amy R. Strom *, Daniel S.W. Lee, Byron Williams, Jeffrey M. Schaub, Elizabeth H. Kellogg, Ilya J. Finkelstein, Luke S. Ferro† Ahmet Yildiz†, and Clifford P. Brangwynne† (* co-first authors) († co-corresponding)
Dev Cell. 57 (2): 277-290.e9
[PDF]    [Supplement]    DOI: 10.1016/j.devcel.2021.12.017    PMID: 35077681   
 

2021

 
Kamyab Javanmardi†, Chia-Wei Chou, Cynthia Terrace, Ankur Annapareddy, Tamer S. Kaoud, Qingqing Guo, Josh Lutgens, Hayley Zorkic, Andrew P. Horton, Elizabeth C. Gardner, Giaochau Nguyen, Daniel R. Boutz, Jule Goike, Will N. Voss, Hung-Che Kuo, Kevin N. Dalby, Jimmy D. Gollihar & Ilya J. Finkelstein† († co-corresponding)
Mol Cell. 81 (24): 5099-5111.e8
[PDF]    [Supplement]    DOI: 10.1016/j.molcel.2021.11.024    PMID: 34919820   
 
James R. Rybarski*, Kuang Hu*, Alexis M. Hill*, Claus O. Wilke, Ilya J. Finkelstein (* co-first authors)
PNAS. 118 (49): e2112279118
[PDF]    [Supplement]    DOI: 10.1073/pnas.2112279118    PMID: 34845024   
 
Alexis M. Hill*, James R. Rybarski*, Kuang Hu, Ilya J. Finkelstein, and Claus O. Wilke(* co-first authors)
Journal of Open Source Software.
[PDF]    DOI: 10.21105/joss.03678    PMID: 35445164   
 
Jeffrey M. Schaub*, Chia-Wei Chou*, Hung-Che Kuo*, Kamyab Javanmardi*, Ching-Lin Hsieh, Jory Goldsmith, Andrea M. DiVenere, Kevin C. Le, Daniel Wrapp, Patrick O. Byrne, Christy K. Hjorth, Nicole V. Johnson, John Ludes-Meyers, Annalee W. Nguyen, Nianshuang Wang, Jason J. Lavinder, Gregory C. Ippolito, Jennifer A. Maynard, Jason S. McLellan, and Ilya J. Finkelstein (* co-first authors)
Nat Protoc.
[PDF]    DOI: 10.1038/s41596-021-00623-0    PMID: 34611365   
 
Molly S. Blevins, Jada N. Walker, Jeffrey M. Schaub, Ilya J. Finkelstein and Jennifer S. Brodbelt
Chem Sci. 12 (41): 13764-13776
[PDF]    [Supplement]    DOI: 10.1039/d1sc02861h    PMID: 34760161   
 
Chien-Hui Ma, Kamyab Javanmardi, Ilya J. Finkelstein†, Makkuni Jayaram† († co-corresponding)
eLife.
[PDF]    [Supplement]    DOI: 10.7554/eLife.65763    PMID: 34435949   
 
Randall J. Olsen, Paul A. Christensen*, S. Wesley Long*, Sishir Subedi*, Parsa Hodjat, Robert Olson, Marcus Nguyen, James J. Davis, Prasanti Yerramilli, Matthew Odeja Saavedra, Lanye Pruitt, Kristina Reppond, Madison N. Shyer, Jessica Cambric, Ryan Gaad, Rashi M. Thakur, Akanksha Batajoo, Ilya J. Finkelstein, Jimmy Gollihar, and James M. Musser (* co-authors)
American Journal of Pathology. 191 (10): 1754-1773
[PDF]    DOI: 10.1016/j.ajpath.2021.07.002    PMID: 34303698   
 
William N. Voss, Yixuan J. Hou, Nicole V. Johnson, George Delidakis, Jin Eyun Kim, Kamyab Javanmardi, Andrew P. Horton, Foteini Bartzoka, Chelsea J. Paresi, Yuri Tanno, Chia-Wei Chou, Shawn A. Abbasi, Whitney Pickens, Katia George, Daniel R. Boutz, Dalton M. Towers, Jonathan R. McDaniel, Dnaiel Billick, Jule Goike, Lori Rowe, Dhwani Batra, Jan Pohl, Justin Lee, Shivaprakash Gangappa, Suryaprakash Sambhara, Michelle Gadush, Nianshuang Wang, Maria D. Person, Brent L. Iverson, Jimmy D. Gollihar, John Dye, Andrew Herbert, Ilya J. Finkelstein, Ralph S. Baric, Jason S. McLellan, George Georgiou, Jason L. Lavinder†, Gregory C. Ippolito† († co-corresponding)
Science. 372 (6546): 1108-1112
[PDF]    [Supplement]    DOI: 10.1126/science.abg5268    PMID: 33947773   
 
Carlos Calcines-Cruz, Ilya J. Finkelstein† & Armando Hernandez-Garcia† († co-corresponding)
Nano Letters. 21 (7): 2752-2757
[PDF]    [Supplement]    DOI: 10.1021/acs.nanolett.0c04640    PMID: 33729813   
 
S. Wesley Long, Randall J. Olsen, Paul A. Christensen, Sishir Subedi, Robert Olson, James J. Davis, Matthew Ojeda Saavedra, Prasanti Yerramilli, Layne Pruitt, Kristina Reppond, Madison N. Shyer, Jessica Cambric, Ilya J. Finkelstein, Jimmy Gollihar, James M. Musser(* co-first authors) († co-corresponding)
American Journal of Pathology. 191 (6): 983-992
[PDF]    DOI: 10.1016/j.ajpath.2021.03.004    PMID: 33741335   
 
Isabel Strohkendl, Fatema A. Saifuddin, Bryan A. Gibson, Michael K. Rosen, Rick Russell† & Ilya J. Finkelstein† († co-corresponding)
Science Advances. 7 (11): eabd6030
[PDF]    [Supplement]    DOI: 10.1126/sciadv.abd6030    PMID: 33692102   
 

2020

 
Scott Wesley Long*, Randall J. Olsen*, Paul A. Christensen*, David W. Bernard, James J. Davis, Maulik Shukla, Marcus Nguyen, Matthew Ojeda Saavedra, Prasanti Yerramilli, Layne Pruitt, Sishir Subedi, Hung-Che Kuo, Heather Hendrickson, Ghazaleh Eskandari, Hoang A.T. Nguyen, J. Hunter Long, Muthiah Kumaraswami, Jule Goike, Daniel Boutz, Jimmy Gollihar, Jason S. McLellan, Chia-Wei Chou, Kamyab Javanmardi, Ilya J. Finkelstein & James Musser (* co-first authors)
mBio. 11 (6): e02707-20
[PDF]    DOI: 10.1128/mBio.02707-20    PMID: 33127862    
 
Stephen K. Jones Jr.*, John A. Hawkins*, Nicole V. Johnson, Cheulhee Jung, Kuang Hu, James R. Rybarski, Janice S. Chen, Jennifer A. Doudna, William H. Press & Ilya J. Finkelstein; (* co-first authors)
Nature Biotechnology.
[PDF]    [Supplement]    DOI: 10.1038/s41587-020-0646-5    PMID: 32895548   
 
Corey Frazer*, Mae I. Staples*, Yoori Kim, Matthew Hirakawa, Maureen A. Dowell, Nicole V. Johnson, Aaron D. Hernday, Veronica H. Ryan, Nicolas L. Fawzi, Ilya J. Finkelstein & Richard J. Bennett (* co-first authors)
Nature Microbiology.
[PDF]    DOI: 10.1038/s41564-020-0760-7    PMID: 32719507   
 
Ching-Lin Hsieh, Jory A. Goldsmith, Jeffrey M. Schaub, Andrea M. DiVenere, Hung-Che Kuo, Kamyab Javanmardi, Kevin C. Le, Daniel Wrapp, Alison Gene-Wei Lee, Yutong Liu, Chia-Wei Chou, Patrick O. Byrne, Christy K. Hjorth, Nicole V. Johnson, John Ludes-Meyers, Annalee W. Nguyen, Juyeon Park, Nianshuang Wang, Dzifa Amengor, Jason J. Lavinder, Gregory C. Ippolito, Jennifer A. Maynard†, Ilya J. Finkelstein† & Jason S. McLellan† († co-corresponding)
Science. 369 (6510): 1501-1505
[PDF]    [Supplement]    DOI: 10.1126/science.abd0826    PMID: 32703906   

Press:

 
 
Hongshan Zhang, Jeffrey M. Schaub & Ilya J. Finkelstein
Nucleic Acids Research. 48 (14): 7834-7843
[PDF]    [Supplement]    DOI: 10.1093/nar/gkaa559    PMID: 32621611    
 
 
Rajashree Deshpande, Logan Myler, Michael Soniat, Nodar Makharashvili, Linda Lee, Susan Lees-Miller, Ilya Finkelstein & Tanya Paull
Science Advances. 6 (2): eaay0922
[PDF]    [Supplement]    DOI: 10.1126/sciadv.aay0922    PMID: 31934630   

Please see https://finkelsteinlab.org/papers/ for all papers

 

Awards

2021                      Norman Hackerman Award in Chemical Sciences, Welch Foundation

2018                      Fellow, William H. Tonn Professorial Fund

2015                      National Science Foundation CAREER Award                    

2014                      American Federation of Aging Research Junior Fellow

2013                      Emerging Investigator, Molecular BioSystems

2013                      Protege, The Academy of Medicine, Engineering and Science of Texas

2012                      CPRIT Fellow in Cancer Research                           

2011                      Pathway to Independence Award (NIH K99/R00)                                        

2007                      NRSA Postdoctoral Fellow (NIH F32)

BCH339M: Structure and Function of Molecular Machines

An updated list of current lab members is available on the Finkelstein lab website.

Interested in joining the team?

The Finkelstein group is an interdisciplinary team of biophysicists seeking to discover how molecular machines maintain and edit our genetic information. We combine molecular biology with high-throughput approaches and single-molecule biophysics. We are especially interested in scientists that are at the interface of biophysics, bioinformatics, and molecular biology. For specific job openings, see below:

Postdoc Openings

Applicants with a strong background in bioinformatics, molecular (bio)physics, biomedical engineering, or computer science are strongly encouraged to apply. However, enthusiasm and a strong work ethic in your graduate career are the only requirements. Please email Ilya a CV and a cover letter that explains why you are interested in the lab.

Graduate Students

Prospective graduate students that are interested in molecular biophysics, bioinformatics, or biomedical engineering can join the lab by applying to a number of graduate programs at UT Austin. Possibilities include:

Undergraduate Students

The laboratory strives to include exceptional undergraduates with prior research experience in the life of the lab. To get started in research, please apply to these or related Freshman Research Initiative streams:

Students that are interested in joining the lab are encouraged to e-mail Ilya a short (one-page) summary of their prior research project. Unfortunately, I cannot consider applications without a one-page research summary.