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Center for Systems and Synthetic Biology

The Center for Systems and Synthetic Biology (CSSB) brings together UT researchers across a range of disciplines to quantitatively understand and engineer the regulatory networks underlying organismal biology.

Our research interests include:

  • Disease: Developing computer models to better understand a multitude of human diseases and crop traits.
  • Drugs: Discovering drugs based on genetic modules shared between humans and organisms as distant as yeast.
  • Developing diagnostics for resource-limited settings using smart molecular amplifiers.
  • Immunity: Using cutting-edge genome sequence technology to map immune responses.
  • Emerging viruses: Finding methods to predict the emergence of the next threats.
  • Molecular computation:  Developing programmable molecules that contribute to sensors, amplifiers, and organismal operating systems.

Research at the CSSB is focused on the integration of genomics, proteomics, and metabolomics data—offering a more unified view of organisms as integrated networks. Such systems-wide, interdisciplinary approaches allow us to better define the functions of genes, and to accelerate the discovery of new pathways that are critical for various traits and diseases.

Selected projects include: Diagnostics for Developing Markets. Discovering New Disease Genes, Pathways, and Drugs.

HIV/AIDS: An Ongoing Global Pandemic. Two of their contributions to this field are already being translated to public health:

  • Development of a synthetic gene that protects against HIV, which is now under therapeutic development for the treatment of AIDS.
  • Identification of new genes in the human genome that may help define disease progression. These genes are currently part of a large, ongoing HIV/AIDS association study being conducted using HIV/AIDS cohorts.

Emerging Disease: We are currently focusing on influenza, arenaviruses, and Dengue. We are interested in the host genes that make certain species and individuals more prone to infection by these and other viruses.

Baker, Brett
Brett J Baker
Assistant Professor
BARRICK, JEFFREY E
Jeffrey E Barrick
Associate Professor
Microbial experimental evolution and synthetic biology
512-471-3247
MBB 1.436
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Charmichael, Tiffany
Tiffany Carmichael
Financial Analyst
512-232-3426
MBB 3.104
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EHRLICH, LAUREN I
Lauren I Ehrlich
Associate Professor, Associate Professor of Oncology
Thymocyte: stromal cell interactions in T cell development and T-ALL
512-471-7080
NMS 2.314
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ELLINGTON, ANDREW
Andrew Ellington
Professor
Nancy Lee and Perry R. Bass Regents Chair in Molecular Biology | Wilson M. and Kathryn Fraser Research Professorship in Biochemistry

512-232-3424
MBB 3.424
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FINKELSTEIN, ILYA J
Ilya J Finkelstein
Assistant Professor
William H. Tonn Professorial Assistance Fund

Biophysical Studies of Molecular Machines
512-471-1394
MBB 3.422
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GEORGIOU, GEORGE
George Georgiou
Professor
Laura Jennings Turner Chair in Engineering

512-471-6975
CPE 4.410
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Hall, Amelia Weber
Amelia W Hall

I am a 5th year graduate student in the Iyer lab. At present, I study epigenetic regulation in brain cancer.
IYER, VISHWANATH R
Vishy Iyer
Professor, Professor of Oncology
512-232-7833
MBB 3.212A
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KIM, JONGHWAN
Jonghwan Kim
Associate Professor
Transcriptional and epigenetic regulations in Pluripotent stem cells and trophoblast lineage development
512-232-8045
NMS 4.314
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Manning, Schonna
Schonna R Manning
Research Assistant Professor
512-232-1850
BIO
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MARCOTTE, EDWARD M
Edward M Marcotte
Professor
Mr. and Mrs. Corbin J. Robertson, Sr. Regents Chair in Molecular Biology #1

512-232-3919
MBB
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MATOUSCHEK, ANDREAS
Andreas T Matouschek
Professor, Core Facilities Director
Mechanisms of protein machines, protein folding, unfolding, and degradation.
512-232-4045
NMS 4.304
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Maynard, Jennifer
Jennifer A Maynard
Professor
Henry Beckman Professorship in Chemical Engineering

512-471-9188
CPE 5.466
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Ochman, Howard
Howard Ochman
Professor
Joseph J. & Jeanne M. Lagowski Regents Professorship in Molecular Bioscience

512-232-5666
NMS 4.110
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Provost, Sean
Sean Provost
Systems Administrator I
512-232-2632
MBB 3.106
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Qiao, Hong
Hong Qiao
Assistant Professor
SULLIVAN, CHRISTOPHER S
Christopher S Sullivan
Associate Professor
Our lab seeks to understand how viruses interact with the host non-coding RNA machineries to replicate, induce tumors, and cause pathogenesi
512-471-4648
NMS 3.218
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Taylor, David
David W Taylor Jr
Assistant Professor
Directly visualizing molecular machines
512-471-9156
NHB 4.121
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WALLINGFORD, JOHN B
John B Wallingford
Professor
William and Gwyn Shive Endowed Professorship

We combine in vivo imaging with systems biology to explore the cell biological basis of embryonic development
512-232-2784
PAT 222
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WILKE, CLAUS O
Claus O Wilke
Department Chair, Integrative Biology, Professor
Joseph J. & Jeanne M. Lagowski Regents Professorship in Molecular Bioscience | Dwight W. and Blanche Faye Reeder Centennial Fellowship in Systematic and Evolutionary Biology

Department Chair of Integrative Biology. Computational evolutionary biology, Molecular evolution, Virus evolution.
512-232-2459
MBB 3.232
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Yi, Song
Yi, Stephen
Assistant Professor of Oncology, Director of Bioinformatics
512-495-5245
HDB 6.230
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