Nicholas J PriebeAssociate Professor
Department of NeuroscienceMechanisms underlying response properties of neurons in primary sensory cortex using both electrophysiology and imaging in firstname.lastname@example.org
The University of Texas at Austin
Department of Neuroscience, College of Natural Sciences
1 University Station C7000
Austin, TX 78712
I am interested in mechanisms underlying response properties of neurons in primary sensory cortex using both electrophysiology and imaging in vivo. As sensory information moves from the periphery to the cortex the representation of the world is systematically transformed. Understanding the basis for these transformations sheds light on how the brain makes sense of the complicated world in which we reside.
The massive expansion of cerebral cortex is a hallmark of the human brain. We know that the cortex plays an essential role in our perceptions and actions. Sensory inputs from the periphery are transformed in the cortex, allowing us to generate appropriate motor outputs. My lab studies the cortical circuitry and the computations that underlie such transformations, using vision as a model system. In visual cortex, neuronal circuitry performs the computations that extract motion, orientation and depth information about the visual environment from subcortical inputs. For example, primary visual cortex (V1) is the cortical location in which information from the two eyes is first integrated, ultimately allowing us to perceive depth in our visual field. By understanding the circuitry that underlies these kinds of computations, we gain insight into similar computations that occur throughout cortex.
2010 Priebe, N.J., Lampl I. & Ferster D, Mechanisms of direction selectivity in cat primary visual cortex as revealed by visual adaptation, J Neurophys 104: 2615-23
2010 Priebe, N.J. & Ferster, D. , Neuroscience: Each synapse to its own, Nature 464: 1290-1
2008 Priebe, N.J., The relationship between subthreshold and suprathreshold ocular dominance in cat primary visual cortex., J Neurosci 28: 8553-8559
2008 Priebe, N.J. & Ferster, D. , Inhibition, spike threshold and stimulus selectivity in primary visual cortex, Neuron 57: 482-497
2007 Finn IM, Priebe NJ, Ferster D., The emergence of contrast-invariant orientation tuning in simple cells of cat visual cortex., Neuron 54: 137-52
2006 Priebe NJ, Lisberger SG, Movshon JA., Tuning for spatiotemporal frequency and speed in directionally selective neurons of macaque striate cortex., J Neurosci. 26: 2941-50
2006 Priebe, N.J. & Ferster, D. , The mechanism underlying cross-orientation suppression in cat visual cortex, Nature Neuroscience 9: 552-561