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McLellan, Jason

Jason McLellan

Associate Professor
Molecular Biosciences, College of Natural Sciences

The Robert A. Welch Chair in Chemistry

Structural Basis of Host–Pathogen Interactions


Phone: 512-232-1906

Office Location
NHB 4.342

Postal Address
100 E 24TH ST
AUSTIN, TX 78712

Dr. McLellan earned a BS in chemistry with an emphasis in biochemistry from Wayne State University in Detroit, Michigan. Afterward, he obtained his PhD from the Johns Hopkins University School of Medicine in Baltimore, Maryland in the laboratory of Dr. Daniel Leahy. He then carried out postdoctoral research at the National Institutes of Health's Vaccine Research Center in the laboratory of Dr. Peter Kwong and in collaboration with Dr. Barney Graham. In the Fall of 2013, he joined the faculty at the Geisel School of Medicine at Dartmouth in the Department of Biochemistry, and in January 2018 he moved his laboratory to the University of Texas at Austin and became a member of the Department of Molecular Biosciences.

The human body is under constant attack from bacteria, fungi, parasites, and viruses, all of which express proteins that are needed to establish infection and evade the human immune system. We seek to obtain structural information on these proteins and their interactions with host macromolecules and translate this knowledge into the rational development of therapeutic interventions such as small-molecule inhibitors, protective antibodies and stabilized vaccine immunogens. These efforts are highly collaborative and involve domestic and international investigators from academia, government, and industry.

Recent publications:

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes.
Hsieh CL, Goldsmith JA, Schaub JM, DiVenere AM, Kuo HC, Javanmardi K, Le KC, Wrapp D, Lee AG, Liu Y, Chou CW, Byrne PO, Hjorth CK, Johnson NV, Ludes-Meyers J, Nguyen AW, Park J, Wang N, Amengor D, Lavinder JJ, Ippolito GC, Maynard JA, Finkelstein IJ, McLellan JS.
Science. 2020; 369(6510):1501-1505.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies.
Wrapp D, De Vlieger D, Corbett KS, Torres GM, Wang, N, Van Breedam W, Roose K, van Schie L, VIB-CMB COVID-19 Response Team, Hoffmann M, Pöhlmann S, Graham BS, Callewaert N, Schepens B, Saelens X, McLellan JS
Cell. 2020; 181(5):1004-1015.

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS.
Science. 2020; 367(6483):1260-1263.

Structure of the respiratory syncytial virus polymerase complex.
Gilman MSA, Liu C, Fung A, Behera I, Jordan P, Rigaux P, Ysebaert N, Tcherniuk S, Sourimant J, Eléouët J-F, Sutto-Ortiz P, Decroly E, Roymans D, Jin Z, McLellan JS.
Cell. 2019; 179(1):193-204.e114.

Transient opening of trimeric prefusion RSV F proteins.
Gilman MSA, Furmanova-Hollenstein P, Pascual G, van ‘t Wout AB, Langedijk JPM, McLellan JS.
Nat Commun. 2019 May 8;10(1):2105.

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.
Jones HG, Ritschel T, Pascual G, Brakenhoff JPJ, Keogh E, Furmanova-Hollenstein P, Lanckacker E, Wadia JS, Gilman MSA, Williamson RA, Roymans D, van 't Wout AB, Langedijk JP, McLellan JS.
PLoS Pathog. 2018 14(3):e1006935.

Infants infected with respiratory syncytial virus generate potent neutralizing antibodies that lack somatic hypermutation.
Goodwin E, Gilman MSA, Wrapp D, Chen M, Ngwuta JO, Moin SM, Bai P, Sivasubramanian A, Connor RI, Wright PF, Graham BS, McLellan JS, Walker LM.
Immunity 2018; 48(2):339-349.e5.

Structure and immunogenicity of prefusion-stabilized human metapneumovirus F glycoprotein.
Battles MB, Más V, Olmedillas E, Cano O, Vázquez M, Rodríguez L, Melero JA, McLellan JS.
Nat Commun. 2017 Nov 16;8(1):1528.

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS.
PNAS 2017 Aug 29;114(35):E7348-E7357. 

View all of Dr. McLellan's publications on PubMed

2019 Viruses Young Investigator in Virology Prize

2018 American Crystallographic Association Etter Early Career Award

2015 Charles H. Hood Foundation Child Health Research Award

2012 Norman P. Salzman Memorial Award in Virology